Publications
70. Arene and Heteroarene Functionalization Enabled by Organic Photoredox Catalysis
Zhu, Z.; Wu, X.; Li, Z.; Nicewicz, D.A. Acc. Chem. Res. 2025, XXXX, XXX, XXX-XXX
69. Synthesis of Biaryl Atropisomers via Site-Selective C–H Functionalization
Genova, J.C.; Nicewicz, D.A. Org. Lett., 2025, 27 (8), 1889-1894
68. Programmable Piperazine Synthesis via Organic Photoredox Catalysis
Boley, A.J.; Genova, J.C.; Nicewicz, D.A.; J. Am. Chem. Soc. 2024, 146 (45), 31274-31280
67. Carbon Isotopic Labelling of Carboxylic Acids Enabled By Organic Photoredox-Catalyzed Cyanation
Zhu, Z.; Wu, X.; Bida, G.T.; Deng, H.; Ma, X.; Qian, S.; Wu, Z.; Li, Z.; Nicewicz, D.A. Nat. Synth., 2024
66. One-Step Synthesis of [18F]Aromatic Electrophile Prosthetic Groups via Organic Photoredox Catalysis
Li. M.; Staton, C.; Ma. X.; Zhao. W.; Pan. L.; Giglio.G.; Berton. H.S.; Wu. Z.; Nicewicz, D.A.; Li, Z. ACS. Cent. Sci., 2024, 10, 1609-1618
65. Alkoxy Radical Generation Mediated by Sulfoxide Cation Radicals for Alcohol-Directed Aliphatic C–H Functionalization
Finis, D.S.; Nicewicz, D. A.;. J. Am. Chem. Soc., 2024, 146, 24, 16830-16837
64. Enantioselective Amino- and Oxycyanation of Alkenes via Organic Photoredox and Copper Catalysis
Qian, S.; Lazarus, T.M.; Nicewicz, D.A. J. Am. Chem. Soc., 2023, 145, 33, 18247-18252
63. Divergent Functionalization of Alkynes Enabled by Organic Photoredox Catalysis
Zhu, Z.; Qian, S.; Nicewicz, D. A.; Li, Z. Synlett. 2023
62. 11C-, 12-C, and 13-C Cyanation of Electron-Rich Arenes via Organic Photoredox Catalysis
Wu, X.; Chen, W.; Holmgberg-Douglas, N.; Bida, G.T.; Tu, X.; Ma, X.; Wu, Z.; Nicewicz, D.A.; Li, Z. Chem, 2023
61. Direct C-H Radiocyanation of Arenes via Organic Photoredox Catalysis
Chen, W.; Wu, X.; McManus, J.B.; Bida, G.T.; Li, K.; Wu, Z.; Nicewicz, D. A.; Li, Z. Org. Lett. 2022, 24, 50, 9316-9321
60. Aliphatic C-H Functionalization Using Pyridine N-Oxides as H-Atom Abstraction Agents
Schlegel, M.; Qian, S.; Nicewicz, D. A. ACS Catal. 2022, 12, 16, 10499–10505
59. Mechanistic Investigation into Amination of Unactivated Arene via Cation Radical Accelerated Nucleophilic Aromatic Substitution
Pistritto, V. A.; Liu, S..; Nicewicz, D. A. J. Am. Chem. Soc., 2022, 144, 33, 15118-15131
58. Ketone-Olefin Coupling of Aliphatic and Aromatic Carbonyl Catalyzed by Excited State Acridine Radicals
Venditto, N.J.; Liang, Y.S.; El Mokadem R.K.; Nicewicz, D. A. J. Am. Chem. Soc. 2022, 144, 26, 11888–11896
57. Arene Radiofluorination Enabled by Photoredox-Mediated Halide Interconversion
Chen, W.; Wang, H.; Tay, N. E. S.; Pistritto, V. A.; Li, K.-P.; Wu, Z.; Nicewicz, D. A.; Li, Z. Nat. Chem, 2022, 14, 216-223
56. Photoredox-Catalyzed C-H Functionalization Reactions
Holmberg-Douglas, N.; Nicewicz, D. A. Chem. Rev. 2022, 122, 2, 1925–2016
55. Diastereoselective Synthesis of the ABCD Ring System of Rubriflordilactone B
Roth, H.G.; Nicewicz, D. A. Synlett. 2022, 33, 48–51
54. β-Functionalization of Saturated AzaHeterocycles Enabled by Organic Photoredox Catalysis
Holmberg-Douglas, N.; Choi, Y.; Aquila, B.; Huynh, H.; Nicewicz, D. A. ACS Catal. 2021, 11, 3153-3158
53. Milled Dry Ice as a C1 Source for the Carboxylation of Aryl Halides
O’Brien, C. J.; Nicewicz, D. A. Synlett. 2021, 32, 814-816
52. Direct Radiofluorination of Arene C–H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant
Wang, L.; White, A. R.; Chen, W.; Wu, Z.; Nicewicz, D. A.; Li, Z. Org. Lett. 2020, 22, 7971-7975
51. Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis
Pistritto, V. A.; Schutzbach-Horton, M. E.; Nicewicz, D.A. J. Am. Chem. Soc. 2020, 142, 17187-17194.
50. Direct Synthesis of Bicyclic Acetals via Visible Light Catalysis
Wu, F.; Wang, L.; Ji, L.; Zou, G.; Shen, H.; Nicewicz, D.A.; Chen, J.; Huang, Y. iScience 2020, 23, 101395.
49. 19F- and 18F-Arene Deoxyfluorination via Organic Photoredox-Catalysed Polarity-Reversed Nucleophilic Aromatic Substitution
Tay, N.E.S.; Chen W.; Levens, A.; Pistritto, V.A.; Huang, Z; Zhanhong, W.; Zibo, L.; Nicewicz, D.A. Nat. Catal. 2020, 3, 734-742
48. Design and Evaluation of Artificial Hybrid Photoredox Biocatalysts
Schwochert, T. D.; Cruz, C.; Watters, J. W.; Reynolds, E. W.; Nicewicz, D. A.; Brustad, E. ChemBioChem 2020, 21, 3146-3150.
47. Homobenzylic Oxygenation Enabled by Dual Organic Photoredox and Cobalt Catalysis
McManus, J. B.*; Griffin, J. D.*; White, A. R.; Nicewicz, D. A. J. Am. Chem. Soc. 2020, 142, 23, 10325–10330
46. Cation Radical-Accelerated Nucleophilic Aromatic Substitution for Amination of Alkoxyarenes
Venditto, N. J.; Nicewicz, D. A. Org. Lett. 2020, 22, 12, 4817–4822
45. Development of a Large-Enrollment Course-Based Research Experience in an Undergraduate Organic Chemistry Laboratory: Structure–Function Relationships in Pyrylium Photoredox Catalysts
Cruz, C. L.; Holmberg-Douglas, N.; Onuska, N. P. R.; McManus, J. B.; MacKenzie, I. A.; Hudson, B.L.; Eskew, N. A.; Nicewicz, D. A. J. Chem. Educ. 2020, 97, 6, 1572–1578
44. Discovery and Characterization of Acridine Radical Photoreductants.
MacKenzie, I. A.; Wang, L.; Onuska, N. P. R.; Williams, O. F.; Begam, K.; Moran, A. M.; Dunietz, B. D.; Nicewicz, D. A. Nature, 2020, 580, 76-80.
43. Regioselective Arene C–H Alkylation Enabled by Organic Photoredox Catalysis
Holmberg-Douglas, N.; Onuska, N. P. R.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2020, 59, 7425-7429
42. Site-Selective C–H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis.
McManus, J. B.; Onuska, N. P. R.; Jeffreys, M. S.; Goodwin, N. C.; Nicewicz, D. A. Org. Lett. 2020, 22, 679-683
41. Anti-Markovnikov Hydroazidation of Activated Olefins via Organic Photoredox Catalysis
Onuska, N. P. R.; Schutzbach-Horton, M. E.; Rosario Collazo, J. L.; Nicewicz, D. A. Synlett, 2020, 31, 55-59
40. Arene Cyanation via Cation Radical Accelerated Nucleophilic Aromatic Substitution
Holmberg-Douglas, N.; Nicewicz, D. A. Org. Lett. 2019, 21, 7114-7118
39. Alcohol Mediated Degenerate Chain Transfer Controlled Cationic Polymerization of Para-Alkoxystyrene
Prasher, A.; Hu, H.; Tanaka, J.; Nicewicz, D. A.; You, W. Polym. Chem. 2019, 10, 4126-4133
38. Arene C-H Fluorination with 18F– via Organic Photoredox Catalysis
Chen, W.; Huang, Z.; Tay, N. E. S.; Giglio, B.; Wang, M.; Wang, H.; Wu, Z.; Nicewicz, D. A.; Li, Z. Science, 2019, 364, 1179-1174
37. Synthesis and Characterization of Acridinium Dyes for Photoredox Catalysis
White, A. R.; Wang, L.; Nicewicz, D. A. Synlett 2019, 30, 827-832
36. Mechanistic Investigations Into the Cation Radical Newman-Kwart Rearrangment
Cruz, C. L.; Nicewicz, D. A. ACS Catal. 2019, 9, 3926-3935
35. Generation and Alkylation of α–Carbamyl Radicals via Organic Photoredox Catalysis
McManus, J. B.; Onuska, N. P. R.; Nicewicz, D. A. J. Am. Chem. Soc. 2018, 140, 9056-9060
34. Enantioselective Counter Anions in Photoredox Catalysis: The Asymmetric Cation Radical Diels-Alder Reaction
Morse, P. D.; Nguyen, T. M.; Cruz, C. L.; Nicewicz, D. A. Tetrahedron 2018, 74, 3266-3272
33. A General Strategy for Aliphatic C–H Functionalization Enabled by Organic Photoredox Catalysis
Margrey, K. A.; Czaplyski, W. L.; Nicewicz, D. A.; Alexanian, E. J. J. Am. Chem. Soc. 2018, 140, 4213-4217
32. Direct Synthesis of Polysubstituted Aldehydes via Visible Light-Catalysis
Wu, F.; Wang, L.; Chen, J.; Nicewicz, D. A.; Huang, Y. Angew. Chem. Int. Ed. 2018, 57, 2174-2178
31. Cation Radical-Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis
Tay, N. E.; Nicewicz, D. A. J. Am. Chem. Soc. 2017, 139, 16100-16104
30. Direct C–H Arylation of Primary Amines via Organic Photoredox Catalysis
Margrey, K. A.; Levens, A.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2017, 56, 15644-15648
29. Oxidation of Alkyl Benzenes by a Flavin Photooxidation Catalyst on Nano-Structured Metal Oxide Films
Dongare, P.; MacKenzie, I; Wang, D.; Nicewicz, D. A.; Meyer, T. J. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 9279-9283
28. Predictive Model for Site-Selective Aryl and Heteroaryl C-H Amination via Organic Photoredox Catalysis
Margrey, K. A.; McManus, J. B.; Bonazzi, S.; Zecri, F.; Nicewicz, D. A. J. Am. Chem. Soc. 2017, 139, 11288-11299
27. Visible Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives
Wang, L.; Wu, F.; Chen, J.; Nicewicz, D. A.; Huang, Y. Angew. Chem. Int. Ed. 2017, 56, 6896-6900
26. Direct C–H Cyanation of Arenes via Organic Photoredox Catalysis
McManus, J. B.; Nicewicz, D. A. J. Am. Chem. Soc. 2017, 139, 2880-2883
25. Reversing the Regioselectivity of Halofunctionalization Reactions via Cooperative Photoredox and Copper Catalysis
Griffin, J. D.; Cavanaugh, C. L.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2017, 56, 2097-2100
24. A General Approach to Catalytic Alkene Anti-Markovnikov Hydrofunctionalization Reactions via Acridinium Photoredox Catalysis
Margrey, K. A.; Nicewicz, D. A. Acc. Chem. Res. 2016, 49, 1997-2006
23. Acridinium-Based Photocatalysts: A Sustainable Option in Photoredox Catalysis
Joshi-Pangu, A.; Lévesque, F.; Roth, H. G.; Oliver, S. F.; Campeau, L.-C.; Nicewicz, D., DiRocco, D. A. J. Org. Chem. 2016, 81, 7244-7249
22. Organic Photoredox Catalysis
Romero, N. A.; Nicewicz, D. A. Chem. Rev. 2016, 116, 10075-10166
21. Experimental and Calculated Electrochemical Potentials of Common Organic Molecules for Applications to Single Electron Redox Chemistry
Roth, H. G.; Romero, N. A.; Nicewicz, D. A. Synlett, 2016, 27, 714-723
20. An Ambient Temperature Newman-Kwart Rearrangement Mediated by Organic Photoredox Catalysis
Perkowski, A. J.; Cruz, C. L.; Nicewicz, D. A. J. Am. Chem. Soc., 2015, 137, 15684-15687
19. Synthesis of a-Benzyloxyamino-g-Butyrolactones via a Polar Radical Crossover Cycloaddition Reaction
Cavanaugh, C. L.; Nicewicz, D. A. Org. Lett., 2015, 17, 6082-6085
18. Site-Selective Arene C–H Amination via Photoredox Catalysis
Romero, N. A.; Margrey, K. A.; Tay, N. E.; Nicewicz, D. A. Science, 2015, 349, 1326-1330
17. Hydrodecarboxylation of Carboxylic and Malonic Acid Derivatives via Organic Photoredox Catalysis: Substrate Scope and Mechanistic Insight
Griffin, J. D.; Zeller, M. A.; Nicewicz, D. A. J. Am. Chem. Soc. 2015, 137, 11340-11348
16. Visible Light Photoinitiated Metal-Free Living Cationic Polymerization of 4-Methoxystyrene
Perkowski, A. J.; You, W.; Nicewicz, D. A. J. Am. Chem. Soc. 2015, 137, 7580-7583
15. Amide and Amine Nucleophiles in Polar Radical Crossover Cycloadditions: Synthesis of g-Lactams and Pyrrolidines
Gesmundo, N. J.; Grandjean, J. M.; Nicewicz, D. A. Org. Lett. 2015, 17, 1316-1319
14. Divergent Regioselectivity in Photoredox-Catalyzed Hydrofunctionalization Reactions of Unsaturated Amides and Thioamides
Morse, P. D.; Nicewicz, D. A. Chem. Sci. 2015, 6, 270-274
13. Mechanistic Insight into the Photoredox Catalysis of Anti-Markovnikov Alkene Hydrofunctionalization Reactions
Romero, N.; Nicewicz, D. A. J. Am. Chem. Soc. 2014, 136, 17024-17035
12. g-Butyrolactone Synthesis via Polar Radical Crossover Cycloaddition Reactions: Diastereoselective Synthesis of Methylenolactocin and Protolichesterinic Acid
Zeller, M. A.; Riener, M.; Nicewicz, D. A. Org. Lett. 2014, 16, 4810-4813
11. Direct Anti-Markovnikov Addition of Mineral Acids to Styrenes
Wilger, D. J.; Grandjean, J. M.; Lammert, T.; Nicewicz, D. A. Nature Chem. 2014, 6, 720-726
10. Cyclization-Endoperoxidation Cascade Reactions of Dienes Mediated by a Pyrylium Photoredox Catalyst
Gesmundo, N. J.; Nicewicz, D. A. Beilstein J. Org. Chem. 2014, 10, 1272-1281
9. Anti-Markovnikov Hydroamination of Alkenes Catalyzed by a Two-Component Organic Photoredox System: Direct Access to Phenethylamine Derivatives
Nguyen, T. M.; Manohar, N.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2014, 53, 6198-6201
8. Organic Photoredox Catalysis as a General Strategy for Anti-Markovnikov Hydrofunctionalization
Nicewicz, D. A.; Hamilton, D. S. Synlett 2014, 25, 1191-1196
7. Recent Applications of Organic Dyes as Photoredox Catalysts
Nicewicz, D. A.; Nguyen, T. M. ACS Catal. 2014, 4, 355-360
6. Direct Catalytic Anti-Markovnikov Addition of Carboxylic Acids to Alkenes
Nicewicz, D. A.; Hamilton, D. S. J. Am. Chem. Soc. 2013, 135, 10334-10337
5. Anti-Markovnikov Hydroamination of Alkenes Catalyzed by an Organic Photoredox System
Nguyen, T. M.; Nicewicz, D. A. J. Am. Chem. Soc. 2013, 135, 9588-9591
4. Catalytic Hydrotrifluoromethylation of Styrenes and Unactivated Aliphatic Alkenes via an Organic Photoredox System
Wilger, D. J.; Gesmundo, N. J.; Nicewicz, D. A.. Chem. Sci. 2013, 4, 3160-3165
3. Synthesis of Cyclobutane Lignans via an Organic Single Electron Oxidant-Electron Relay System
Riener, M.; Nicewicz, D. A. Chem. Sci. 2013, 4, 2625-2629
2. Synthesis of Highly Substituted Tetrahydrofurans via Catalytic Polar-Radical Crossover Cycloadditions of Alkenes and Alkenols
Grandjean, J.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2013, 52, 3967-3971
1. Direct Catalytic Anti-Markovnikov Hydroetherification of Alkenols
Hamilton, D. S.; Nicewicz, D. A. J. Am. Chem. Soc. 2012, 134, 18577-18580